The flames close, to crack the three storey block in Morton Wallington, about 0030 BST.
A second floor flat "considerable" damage, London fire said Brigade.
Five people fled the building before firefighters arrive. A woman with Burns was taken to the ambulance and their condition is unknown.
Firefighters cut off the gas and electricity to the building that stands out from the fenced-off,.
The cause of the explosion is examined.
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