Some 30 people are reported in the explosion have wounded.
The police say that the explosion was caused by a bomb, an illegal Joss House run by a band of local crimes rocked.
Officials told the BBC that the nature of the bomb can be assumed that it was planted by Islamic militants.
A report has said the the was known as the Rummy-Club, and is in a poorer part of in the South of the city, where gambling is illegal but popular an activity.
Shrapnel
The attack occurred in the District of Lyari, where gangs operate a number of warring drugs and weapons.
The bomb was planted inside a room within the den and detonated by remote control, police officer told the BBC.
Officials say the high number of casualties due to a large number of people packed the Chambers in the.
The police said that the high number of people in the rooms meant that the death toll was particularly highEyewitnesses described as shrapnel from the bomb through sacrifice, kill many immediately torn.
The city, Pakistan's commercial capital, has seen a number of political and ethnic attacks, which last year killed 775 people.
Some are believed to criminal gangs responsible, but the BBC's Shoaib Hasan in Karachi says, that the level of sophistication of the bomber used suggest that it was planted by rival criminal gangs but was rather the work of militant Islamist.
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