The protesters called while some the overthrow of President Bashar al-Assad for reforms required.
The protests in Damascus and other cities are probably the largest in a month riots in which about 200 people reported killed.
Mr Assad has made while on dissent some concessions.
Thousands of people have been reported places where violence previously reported, demonstrated in a number of other Syrian cities, including Deraa, Latakia, Baniyas, and Al Qamishli.
State media reported that "small demonstrations" in various parts of the country had taken place and security forces do not intervene.
Yellow card warningThe mass protest in the suburbs of Damascus marked a major escalation of Syria's month unrest, which has largely bypassed the capital.
Continue reading the most important storyit's time for the Syrian Government to stop suppressing its citizens and respond to their efforts to launch "end quote Hillary Clinton U.S. Secretary of State analysts said Friday's protests were the largest since she began in the southern town of Deraa on 15 March."
The unrest is seen as the biggest challenge Mr Assad, in the year 2000 makes inherited from his father.
The protesters say they want greater freedom, including a lifting of the decades old security law, which prohibits public gatherings of more than five people.
Some are calling for the overthrow of the President, the with firmly in control by his family and the security forces of rules.
Mr Assad has offered some concessions, forming the new Government on Thursday and pronouncing amnesty for an undisclosed number of people detained in the last month.
He has also some local officials dismissed and Syrian citizenship to thousands of the country's Kurdish minority - one long-held demand meet.
The protesters in Damascus but yellow cards in a football style warning to President Assad, said the news agency AP.
"This is our first warning, the next time we come up with the red cards, is", a protestor said.
'Legitimate demands'Other witnesses said that the protesters down posters of Mr Assad crack it passed their route and called for the overthrow of the President.
A witness who said, people in the streets North of the town's Abbasside main square 15 bus loads of secret police had hunted quoted Reuters.
The United Nations and a number of Western Governments have complained to try President Assad use of force to quash the protests.
US Secretary of State Hillary Clinton calls Syrian authorities to stop violence against their own people.
"The Syrian Government not the legitimate demands of the Syrian people is addressed," she said after a NATO meeting in Berlin.
"It is time for the Syrian Government to stop suppressing its citizens and respond to their aspirations to start."
Human rights activists say hundreds of people about Syria including opposition figures, bloggers and activists were arrested.
Mr Assad blames the violence in recent weeks armed gangs, which instead reform seekers and has vowed to put down more unrest.
US officials said Iran help Syria, the protests, a charge down on have denied Tehran and Damascus.
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